Annotated Bibliography 1
This is a graphic organizer and reflection paragraph about a collection of research papers discussing advancements in the biomedical engineering field.
Feng. Liu et al. “New Frontiers in Biomedical Science and Engineering during 2014-2015.” Bio-Medical Materials & Engineering, vol. 26, 2015 Supplement1, pp.
S3-S7. EBSCOhost, doi:10.3233/BME-151283.
The editorial containing research papers on the latest advancement in biotechnology and biomedical engineering will help me in understanding the particular machinery used in the lab and the advancements they have led to. By understanding this new technology I can get an overview of how the biomedical engineering field has evolved over time and the different products that have emerged.
In addition, the topics the academic journal discussed broadened my knowledge of the field in terms of understanding the different aspects within biomedical engineering. For example, prior to reading this journal I believed that biomedical engineering was just working with biomaterials to make something that will be beneficial to the medical field; however I realized that there are many different studies that one can go into such as, bioinformatics, computational biology, biomedical imaging, and signal processing. This information is especially helpful when researching the specifics of biomedical engineering.
The research papers directed towards advancements in bioactives will primarily be my focus because it will help me understand the effects of extracellular matrix tissue on the body and the beneficial aspects of this type of tissue.
Feng. Liu et al. “New Frontiers in Biomedical Science and Engineering during 2014-2015.” Bio-Medical Materials & Engineering, vol. 26, 2015 Supplement1, pp.
S3-S7. EBSCOhost, doi:10.3233/BME-151283.
The editorial containing research papers on the latest advancement in biotechnology and biomedical engineering will help me in understanding the particular machinery used in the lab and the advancements they have led to. By understanding this new technology I can get an overview of how the biomedical engineering field has evolved over time and the different products that have emerged.
In addition, the topics the academic journal discussed broadened my knowledge of the field in terms of understanding the different aspects within biomedical engineering. For example, prior to reading this journal I believed that biomedical engineering was just working with biomaterials to make something that will be beneficial to the medical field; however I realized that there are many different studies that one can go into such as, bioinformatics, computational biology, biomedical imaging, and signal processing. This information is especially helpful when researching the specifics of biomedical engineering.
The research papers directed towards advancements in bioactives will primarily be my focus because it will help me understand the effects of extracellular matrix tissue on the body and the beneficial aspects of this type of tissue.
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Annotated Bibliography 2
This is a graphic organizer and reflection paragraph about the functions of extracellular matrix tissue.
Lu, Pengfei et al. “Extracellular Matrix Degradation and Remodeling in Development and Disease.” Cold Spring Harbor perspectives in biology 3.12 (2011): 10.1101/cshperspect.a005058 a005058. PMC. Web. 27 Jan. 2018.
This published .gov scholarly article written by authors from credible departments (Paterson Institute for Cancer Research, Department of Anatomy and Program in Developmental Biology, and Department of Surgery and center for Bioengineering and Tissue Regeneration) discusses four main topics: Abnormal vs. Normal properties of ECM tissue, Degradation and Remodeling, Physical Properties, and Environmental Changes. Abnormal ECM can lead to deregulated cell increase, while normal ECM regulates stem cell niches, bone repair, and wound repair. This can be connected to the physical properties of ECM. Clinicians have recognized that diseased tissues have different elasticity (tensile strength) than healthy ones. Furthermore, because the the ECM material can be divided into proteins and glycoproteins, when it stiffens, its biomechanics properties change and cells respond by exerting different kinds of force.
In addition, there are many significant quotes from this article that can help justify my experiment and its results. For example, “The biomechanicanical properties of the ECM belong to a subcategory of its physical properties that determine how the ECM reacts to various forms of force, including tensile, compressive, shear, and other types of force loads applied by cells residing in the matrix.” This quote directly links the the proper functioning of the ECM material to its tensile strength properties. This information can be used to further qualify the fact that environmental effects do in face affect the ECM material. Additionally, the article states that the protein composition is what becomes altered by the environment.
Lu, Pengfei et al. “Extracellular Matrix Degradation and Remodeling in Development and Disease.” Cold Spring Harbor perspectives in biology 3.12 (2011): 10.1101/cshperspect.a005058 a005058. PMC. Web. 27 Jan. 2018.
This published .gov scholarly article written by authors from credible departments (Paterson Institute for Cancer Research, Department of Anatomy and Program in Developmental Biology, and Department of Surgery and center for Bioengineering and Tissue Regeneration) discusses four main topics: Abnormal vs. Normal properties of ECM tissue, Degradation and Remodeling, Physical Properties, and Environmental Changes. Abnormal ECM can lead to deregulated cell increase, while normal ECM regulates stem cell niches, bone repair, and wound repair. This can be connected to the physical properties of ECM. Clinicians have recognized that diseased tissues have different elasticity (tensile strength) than healthy ones. Furthermore, because the the ECM material can be divided into proteins and glycoproteins, when it stiffens, its biomechanics properties change and cells respond by exerting different kinds of force.
In addition, there are many significant quotes from this article that can help justify my experiment and its results. For example, “The biomechanicanical properties of the ECM belong to a subcategory of its physical properties that determine how the ECM reacts to various forms of force, including tensile, compressive, shear, and other types of force loads applied by cells residing in the matrix.” This quote directly links the the proper functioning of the ECM material to its tensile strength properties. This information can be used to further qualify the fact that environmental effects do in face affect the ECM material. Additionally, the article states that the protein composition is what becomes altered by the environment.
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File Size: | 77 kb |
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Annotated Bibliography 3
This is a reflection paragraph about the environmental effect and molecular composition of ECM tissue.
Frantz, Christian, Kathleen M. Stewart, and Valerie M. Weaver. “The Extracellular Matrix at a Glance.” Journal of Cell Science 123.24 (2010): 4195–4200. PMC. Web. 25 Feb. 2018.
This published .gov scholarly article written by Christian Frantz from the Department of Surgery and Center for Bioengineering and Tissue Regeneration, and Kathleen Stewart from the Department of Anatomy at University of California San Fransisco, discusses the importance of ECM in a wide range of syndromes. The article focuses on three main concepts: the molecular composition of ECM, the definition of tissue homeostasis, and ECM tissue aging. Essentially, because ECM is composed of two main classes of macromolecules: proteoglycans and fibrous proteins, they can be easily degraded, which will effect the proper functioning of the material. Furthermore, the authors continue to state, “… collagen fibers are frequently – inappropriately – crosslinked through glycation, by byproducts of lipid oxidation and through exposure to UV light.” This means the mechanical state can impair “ECM organization, and modify epithelial organization and function.”
This article is relevant to my essential question because its central claim is that because ECM tissue is a collection of fibrous proteins, it can be degraded by multiple environments. Therefore, it directly answers the question, proving tensile properties will also be effected. I would be able to use to article to further qualify my claim after conducting my experiment.
Frantz, Christian, Kathleen M. Stewart, and Valerie M. Weaver. “The Extracellular Matrix at a Glance.” Journal of Cell Science 123.24 (2010): 4195–4200. PMC. Web. 25 Feb. 2018.
This published .gov scholarly article written by Christian Frantz from the Department of Surgery and Center for Bioengineering and Tissue Regeneration, and Kathleen Stewart from the Department of Anatomy at University of California San Fransisco, discusses the importance of ECM in a wide range of syndromes. The article focuses on three main concepts: the molecular composition of ECM, the definition of tissue homeostasis, and ECM tissue aging. Essentially, because ECM is composed of two main classes of macromolecules: proteoglycans and fibrous proteins, they can be easily degraded, which will effect the proper functioning of the material. Furthermore, the authors continue to state, “… collagen fibers are frequently – inappropriately – crosslinked through glycation, by byproducts of lipid oxidation and through exposure to UV light.” This means the mechanical state can impair “ECM organization, and modify epithelial organization and function.”
This article is relevant to my essential question because its central claim is that because ECM tissue is a collection of fibrous proteins, it can be degraded by multiple environments. Therefore, it directly answers the question, proving tensile properties will also be effected. I would be able to use to article to further qualify my claim after conducting my experiment.